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School of Medicine

Dr Craig J Smith BSc (Hons) MBChB MD MRCP

Honorary Lecturer

Brain Injury Research Group, Room C238, First Floor, Clinical Sciences Building, Salford Royal Hospital NHS Foundation Trust, Stott Lane, Salford, M6 8HD

 

Role

Consultant in Stroke Medicine at Greater Manchester Neuroscience Centre, Salford Royal Hospitals NHS Foundation Trust; and Honorary Lecturer, Brain Injury Research Group, School of Biomedicine, University of Manchester.

 

Memberships of Committees and Professional Bodies

Membership of The Royal Collge of Physicians (London)

Member of the British Association of Stroke Physicians

Knowledge Mangement Lead, Greater Manchester Cardiac and Stroke Network

Research

Inflammation in cerebrovascular disease: particularly the role of peripheral inflammatory markers in acute stroke

Interleukin-1 blockade as a therapeutic approach in clinical studies of acute cerebral ischaemia

Statins as potential therapeutic agents in acute cerebral ischaemia

Infection complicating acute stroke: underlying mechanisms and potential treatments, including modulation of the innate immune system

Oral hygiene interventions as therapeutic options in stroke

 

Qualifications

BSc (Hons), University of Manchester, 1992 

MBChB, University of Manchester, 1995

MRCP (UK), 1999

MD, University of Manchester, 2004 

 

Collaborators and affiliated staff

Collaborators:

Dr Pippa J Tyrrell, University of Manchester

Dr Steve J Hopkins, University of Manchester

Professor Dame Nancy J Rothwell, University of Manchester

Dr Stuart Allan, University of Manchester

Dr Adam Denes, University of Manchester

Mr Andy Vail, University of Manchester

Dr Hedley C Emsley, Royal Preston Hospital

Dr Maria Horne, University of Manchester

Professor Angus Walls, University of Newcastle

Dr Giles McCracken, University of Newcastle

Dr Mario DiNapoli, Sulmona, Italy

Professor Shaheen Hamdy, University of Manchester

 

Publications

2011

  • Selvarajah JR, Smith CJ, Hulme S, Georgiou R, Sherrington C, Staniland J, Illingworth KJ, Jury F, Payton A, Ollier WE, Vail A, Rothwell NJ, Hopkins SJ, Tyrrell PJ. (2011). Does inflammation predispose to recurrent vascular events after recent transient ischaemic attack and minor stroke? The North West of England transient ischaemic attack and minor stroke (NORTHSTAR) study. Int J Stroke, 6(3), 187-194. eScholarID:132715 | DOI:10.1111/j.1747-4949.2010.00561.x

2010

  • Smith CJ, Tyrrell PJ. (2010). Current and emerging treatments for acute stroke: relationships with infection. Infect Disord Drug Targets, 10(2), 112-121. eScholarID:87335

2008

  • Smith CJ, Ross J, Rothwell NJ, Tyrrell PJ. (2008). Acute neurodegeneration: cerebral ischaemia and stroke. Mechanisms of Disease. (pp. 191-209). New York, US: Cambridge University Press. eScholarID:87336
  • Selvarajah JR, Smith CJ, Hulme S, Georgiou R, Vail A, Tyrrell PJ. (2008). Prognosis in patients with transient ischaemic attack (TIA) and minor stroke attending TIA services in the North West of England: The NORTHSTAR Study. J Neurol Neurosurg Psychiatry, 79, eScholarID:1d16819
  • Emsley H, Smith CJ, Hopkins SJ. (2008). Infection and brain-induced immunodepression after acute ischemic stroke. Stroke, 39( 1), eScholarID:17d350

2007

  • Emsley HC, Smith CJ, Tyrrell PJ, Hopkins SJ. (2007). Inflammation in Acute Ischemic Stroke and its Relevance to Stroke Critical Care. Neurocrit Care, eScholarID:1d16876
  • Emsley, HCA, Smith, CJ, Gavin, CCM, Georgiou, R, Vail, A, Barberan, EM, Illingworth, K, Scarth, S, Wickramasinghe, V, Hoadley, M, Rothwell, NJ, Tyrrell, PJ, Hopkins, SJ. (2007). Clinical outcome following acute ischaemic stroke relates to both activation and autoregulatory inhibition of cytokine production. BMC Neurol, 7, eScholarID:1d16882

2006

  • Smith CJ, Emsley HCA, Vail A, Georgiou R, Rothwell NJ, Tyrrell PJ, Hopkins SJ. (2006). Variability of the systemic acute phase response after ischemic stroke. J Neuro Sci, 251(1-2), eScholarID:1d27470 | DOI:10.1016/j.jns.2006.09.011

2005

  • Di Napoli M, Schwaninger M, Cappelli R, Ceccarelli E, Di Gianfilippo G, Donati C, Emsley HCA, Forconi S, Hopkins SJ, Masotti L, Muir KW, Paciucci A, Papa F, Ronacci S, Sander D, Sander K, Smith CJ, Stefanini A, Weber D. (2005). Evaluation of C-reactive protein measurement for assessing the risk and prognosis in ischemic stroke: a statement for Health Care Professionals from the CRP Pooling Project Members. Stroke, 36, 1316-1329. eScholarID:87334
  • Emsley C A, Smith CJ, Georgiou R, Vail A, Hopkins SJ, Rothwell NJ, Tyrrell PJ. (2005). A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients. Journal of Neurol. Neurosurg. Psychiatry, 76, eScholarID:1d11508 | DOI:10.1136/jnnp.2004.054882
  • Emsley H, Smith CJ, Georgiu R, Vail A, Barberan EM, Rothwell NJ, Tyrrell PJ, Hopkins SJ. (2005). Interleukin-6 and acute ischaemic stroke. Acta Neurol Scand, 112( 4), eScholarID:17d504
  • Emsley, HCA, Smith, CJ, Georgiou, R, Vail, A, Tyrrell, PJ, Barberan, EM, Rothwell, NJ, Hopkins, SJ, Audebert, H, Haberl, RL. (2005). Correlation of systemic inflammatory response with infarct volume in acute ischemic stroke patients. Stroke, 36( 2), eScholarID:17d511

2004

  • Gavin C, Smith CJ, Emsley H, Hughes D, Turnbull I, Vail A, Tyrrell PJ. (2004). Reliability of a semi-automated technique of cerebral infarct volume measurement with CT. Cerebrovasc Dis, 18( 3), eScholarID:1d31875
  • Smith, CJ, Emsley, HCA, Gavin, C, Georgiou, R, Vail, A, Barberan, EM, Del Zoppo, G, Hallenbeck, J, Rothwell, NJ, Hopkins, SJ, Tyrrell, PJ. (2004). Peak Plasma Interleukin-6 and Other Periperhal Markers of Inflammation in tne first week of Ischaemic Stroke Correlate with Brain Infarct Volume, Stroke Severity and Long-term Outcome. BMC Neurology, Jan 15; 4:2, eScholarID:1d7414 | DOI:10.1186/1471-2377-4-2

2003

  • Emsley, HCA, Smith, CJ, Gavin,C.M., Georgiou, R, Vail, A, Barberan,E.M., Hallenbeck,J.M., del Zoppo,G.J., Rothwell, NJ, Tyrrell, PJ, Hopkins, SJ. (2003). An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis. Journal of Neuroimmunology, 139, 1-2, 93-101. eScholarID:1d5582 | DOI:10.1016/S0165-5728(03)00134-6
  • Smith CJ, Staniland J. (2003). A difficult case of inflammatory myositis. Age Ageing, 32( 3), eScholarID:1d32107

2001

  • Smith CJ, Emsley HCA, Libetta CM, Hughes D, Drennan R, Vail A, Tyrrell PJ. (2001). The Oxfordshire Community Stroke Project classification in the early hours of ischemic stroke and relation to infarct site and size on cranial computed tomography. J Stroke Cerebrovasc Dis, 10( 5), eScholarID:1d16880

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