Dr Manikandan Kadirvel BPharm, MPhil, PhD
Research Associate
- Email: Manikandan.Kadirvel@manchester.ac.uk
- Telephone: +44 (0) 161 275 3629
Wolfson Molecular Imaging Centre (WMIC),
School of Cancer and Enabling Sciences,
The University of Manchester,
27 Palatine Road, Manchester. M20 3LJ. UK.
Websites
Wolfson Molecular Imaging Centre (WMIC)
School of Pharmacy and Pharmaceutical Sciences
Research
At WMIC I am working in the development of new labelling strategies directed towards the synthesis of [18F]-radiolabelled compounds for oncology and brain disorder for Positron Emission Tomography (PET) research.
My past research interests have included the synthesis of fluorescent molecular probes for molecular imaging and Auto Inducers (AI-2) (role biofilm formation, and other AI-2 quorum sensing regulated processes). Synthesis of aminoacids (fluorinated derivatives), peptides, polymers (Acrylate 30D copolymer for micro encapsulation), heterocyclic compounds (anti psychotic drugs). Isolation of bioflavonoids from tropical plants of India.
Biography
In November 2009 I joined the WMIC where I am working as a Postdoctoral Research Associate in Radiosynthetic Chemistry/Medicinal Chemistry under the supervision of Dr Gavin Brown.
In 2009 I was awarded a PhD and an MPhil in 2006 by the University of Manchester, Manchester. During that period I was interested in synthesis of fluorescent molecular probes for molecular imaging under the supervision of Dr Sally Freeman. In 2006 I was awarded Overseas Research Studentship and University Research Studentship for 3 years by the University of Manchester.
Prior to moving to the University of Manchester in 2005, I spent 4 years as a process development chemist in a Pharamceutical R&D centre of a leading pharmaceutical company involved in synthesis of Active Pharmaceutical Ingredients (API’s) and custom synthesis. I spent 18 months in a pharmaceutical research institute involved in the isolation of bioflavanoids.
I graduated BPharm from Dr MGR Medical University, Chennai (Madras), India.
Qualifications
2009 - PhD (Medicinal Chemistry), School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, UK.
2006 - MPhil (Medicinal Chemistry), School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, UK.
1999 - BPharm – First class, Dr MGR Medical University, Chennai (Madras), India.
Collaborators and affiliated staff
Publications
2012
- Kadirvel M, Salem Abudalal A, Rajendran R, Gbaj A, Demonacos C and Freeman S. (In-press). myo-Inositol esters of indomethacin as COX-2 inhibitors. Carbohydrate Research, eScholarID:158839
2011
- Kadirvel M., Rattray N. J. W., Rajenderan R., Zalloum W.A., Gbaj A., Demonacos C., Bichenkova* E.V., Freeman* S. (2011). Bioreductive molecular probe: fluorescence signalling upon reduction of an azo group. New J. Chem, 35, 701-708. eScholarID:154729
2010
- Kadirvel M, Stimpson W, Moumene-Afifi S, Arsic B, Glynn N, Halliday N, Williams P, Gilbert P, McBain AJ, Freeman S, Gardiner JM. (2010). Synthesis and bioluminescence inducing properties of autoinducer (S)-4,5-dihydroxypentane-2,3-dione and its enantiomer. Bioorganic and Medicinal Chemistry Letters, 20, 2625-2628. eScholarID:154730
2009
- Freeman. S, Kadirvel. M, Arsic. B, Bichenkova. E. (2009). Inositol based fluorescent probes. COST ACTION ANGIOKEM, CM0602, Inhibitors of angiogenesis: Design, Synthesis and biological exploitation (16-18th October 2009), Certosa di Pontignano, Sienna, Italy, eScholarID:155232
- Ganesan. B, Arsic. B, Kadirvel. M, Barber. J, Sundaram. S, Rao. M. V. (2009). Chemical constituents of Embelia basaal (ROEM. & SCHULT.) DC. Journal of Pharmacy Research, 2, 1575-1578. eScholarID:154731
- Kadirvel. M. (2009). myo-Inositol based fluorescent probes. School of Pharmacy and Pharmaceutical Sciences (5 May 2009), University of Manchester, UK, eScholarID:155229
2008
- Kadirvel M, Arsic B, Freeman S, Bichenkova EV. (2008). Exciplex and excimer molecular probes: detection of conformational flip in a myo-inositol chair. Org. Biomol. Chem, 6, 1966-1972. eScholarID:154732
- Kadirvel M., Gbaj A., Mansell D., Miles S.M., Arsic B., Bichenkova E.V., Freeman S. (2008). Conformational probe: static quenching is reduced upon acid triggered ring flip of a myo-inositol derivative. Tetrahedron, 64, 5598-5603. eScholarID:154733
- Kadirvel. M. (2008). myo-Inositol based fluorescent molecular probes. AstraZeneca Medicinal Chemistry workshop (22-24th October 2008), AstraZeneca, Alderley Park, Cheshire, UK, eScholarID:155230
- Kadirvel. M. (2008). myo-Inositol-indomethacin esters, as potential prodrugs for COX-2 inhibition. 60th Indian Pharmaceutical Congress (12-14th December 2008), New Delhi, India, eScholarID:155231
2006
- Kadirvel M., Bichenkova E.V., D'Emanuele A.J., Freeman S. (2006). Locked energy of axial to equatorial transformation monitored by exciplex and excimer fluorescence. Chem. Lett, 35, 868-869. eScholarID:154734
- Kadirvel. M. (2006). Inositol based Fluorescent Probes. Royal Society of Chemistry (RSC) Chemical Biology Workshop “Carbohydrates at the Chemistry-Biology Interface” School of Biological Sciences (20-21st April 2006), University of Liverpool. UK, eScholarID:155228
- Kadirvel. M. (2006). Locked Energy of Axial to Equatorial Transformation Monitored by Exciplex and Excimer Fluorescence. Royal Society of Chemistry (RSC) “Frontiers in Chemical Biology: Single Molecules conference” (26-29th March 2006), University of Cambridge, UK, eScholarID:155227