[University home]

School of Medicine

Dr Neil K. Gibbs BSc(Bham), MPhil (Lon), PhD (Lon)

Photograph of Neil K. Gibbs

Lecturer in Dermatological Sciences

Dermatological Sciences
University of Manchester Medical School
Stopford Building
Oxford Rd
Manchester
M13 9PT

Dermatological Sciences website

 

Role

  • Medical Y1 and Y2 Portfolio Tutor
  • Medical Foundation Year Lecturer
  • British Photodermatology Group: Founding Secretary and Committee Member (2007-)
  • Journal of Investigative Dermatology: Associate Editor (2007-)
  • Clinical & Experimental Dermatology: Co-Editor (2007-2009)
  • Course External Examiner, Newcastle University; MRes in Medical and Molecular Biosciences (Medical Biotechnology and Enterprise) (2009-)
  • European Society for Photobiology: ex Publications Committee, Executive Committee, Officer
  • Scientific Programme Committees; European Society for Investigative Dermatology; International Photobiology Society; European Society for Photobiology, British Photodermatology Group
  • Founder Curapel Ltd
 

Research

  • Skin barrier function in chronic inflammatory skin diseases
  • Mechanisms of microfibril degradation in skin skin photoageing
  • Primary mechanisms involved in photoimmunosuppresssion and phototherapy
  • The cellular and molecular aetiology of common idiopathic photodermatoses
  • Cellular aspects of xenobiotic-induced skin phototoxicity, photogenotoxicity and photocarcinogenesis
  • Mechanisms of photoprotective gene induction by UVR
 

Teaching

  • Medical Y1 and Y2 Early Experience Portfolio Tutor
  • Medical Foundation Year Lecturer
  • PGR Course Lecturer
  • Staff Development Lecturer
 

Publications

2011

2010

  • Norval M, Gibbs NK. (2010). What's new in photoimmunology? Photodermatology, Photoimmunology and Photomedicine, 26(2), 112-114. eScholarID:80039 | DOI:10.1111/j.1600-0781.2010.00500.x
  • Rhodes, LE, Bock M, Janssens AS, Ling, T, Anastasopoulou L, Antoniou C, Aubin F, Bruckner T, Faivre B, Gibbs, NK, Jansen C, Pavel S, Stratigos A, de Gruijl F, Diepgen T. (2010). Polymorphic light eruption occurs in 18% Europeans and does not exhibit higher prevalence with increasing latitude. Multicentre survey in 6895 individuals residing from the Mediterranean to Scandinavia. Journal Of Investigative Dermatology, 130, 626-628. eScholarID:1d28374 | DOI:10.1038/jid.2009.250
  • Sherratt MJ, Bayley CP, Reilly SM, Gibbs NK, Griffiths CE, Watson RE. (2010). Low-dose ultraviolet radiation selectively degrades chromophore-rich extracellular matrix components. J Pathol, 222, 32-40. eScholarID:110894 | DOI:10.1002/path.2730

2008

  • Gibbs, N., Tye, J. & Norval, M (2008). Recent advances in urocanic acid photochemistry, photobiology and photoimmunology. Photochem Photobiol Sci, 7(6), 655-67. eScholarID:79366 | PMID:18528548 | DOI:10.1039/b717398a

2007

  • Richards, H., Ling, T., Evangelou, G., Brooke, R., Huber, K., Gibbs, N., Fortune, D. & Rhodes, L (2007). Psychologic distress in polymorphous light eruption and its relationship to patients' beliefs about their condition. J Am Acad Dermatol, 56(3), 426-31. eScholarID:79367 | PMID:17184877 | DOI:10.1016/j.jaad.2006.10.035

2006

  • Ling TC, Richards HL, Janssens AS, Anastassopoulou L, Antoniou C, Aubin F, Diepgen TL, Fazakerley R, de Gruijl FR, Jansen CT, Pavel S, Smedley A, Stratigos AJ, Webb AR, Gibbs NK, Rhodes LE. (2006). Seasonal and latitudinal impact of polymorphic light eruption on quality of life. J Invest Dermatol, 126(7), 1648-1651. eScholarID:84933
  • Traynor, N., McKenzie, R., Beckett, G. & Gibbs, N (2006). Selenomethionine inhibits ultraviolet radiation-induced p53 transactivation. Photodermatol Photoimmunol Photomed, 22(6), 297-303. eScholarID:79368 | PMID:17100737 | DOI:10.1111/j.1600-0781.2006.00256.x

2005

  • Winhoven SM, Blackburn A, Griffiths CEM, Gibbs NK. (2005). Paul Langerhans: the man and 'his' cell. Academic Press. eScholarID:2d1744
  • McLoone, P., Simics, E., Barton, A., Norval, M. & Gibbs, N (2005). An action spectrum for the production of cis-urocanic acid in human skin in vivo. J Invest Dermatol, 124(5), 1071-4. eScholarID:79369 | PMID:15854050 | DOI:10.1111/j.0022-202X.2005.23731.x

2004

  • Blackburn A, Ling TC, Brownrigg M, Rhodes LE, Gibbs NK. (2004). UVB-induced Langerhans' cell trafficking in polymorphic light eruption. Academic Press. eScholarID:2d1584
  • Ling T, Richards HL, Brownrigg M, Brooke RCC, Gibbs NK, Rhodes LE. (2004). Psychological distress in polymorphic light eruption. Academic Press. eScholarID:2d1300
  • McLoone, P., Man, I., Yule, S., Fluitman, A., Van Loveren, H., Norval, M. & Gibbs, N (2004). Whole-body UVB (TL-01) or UVA-1 irradiation does not alter the levels of immunomodulatory cytokines in the serum of human volunteers. Photodermatol Photoimmunol Photomed, 20(2), 76-80. eScholarID:79370 | PMID:15030591 | DOI:10.1111/j.1600-0781.2004.00089.x
  • P McLoone, I Man, S Yule, A Fluitman, H Van Loveren, M Norval, Gibbs NK. (2004). Whole-body UVB (TL-01) or UVA-1 irradiation does not alter the levels of immunomodulatory cytokines in the serum of human volunteers. Photodermatol Photoimmunol Photomed, 20, 76-80. eScholarID:1d9792 | DOI:10.1111/j.1600-0781.2004.00089.x

2003

  • A Blackburn, Watson REB, Gibbs NK. (2003). Distribution of fibrillin-1 and fibrillin-rich microfibrils in murine skin chronically exposed to low-dose UVB radiation. eScholarID:2d1756
  • Ling T, Gibbs NK, Rhodes LE. (2003). Treatment of polymorphic light eruption. Photodermatol Photoimmunol Photomed, 19(5), 217-227. eScholarID:1d25507
  • Ling, T., Gibbs, N. & Rhodes, L (2003). Treatment of polymorphic light eruption. Photodermatol Photoimmunol Photomed, 19(5), 217-27. eScholarID:79371 | PMID:14535892
  • Gibbs NK. (2003). Narrowband UV-B phototherapy clears psoriasis through a combination of local and systemic effects. Arch Dermatol, 139(5), 665. eScholarID:79414
  • Gibbs NK. (2003). Narrowband UV-B phototherapy clears psoriasis through a combination of local and systemic effects. Arch Dermatol, 139, 665-666. eScholarID:17d199

2002

  • S Kuo, H Autrup, C Henderson, R Wolf, Gibbs NK. (2002). UVB radiation is a weak inducer of cytochrome P450 1A1 in mouse skin. eScholarID:2d1847
  • Y Chatelus, Watson REB, Gibbs NK. (2002). Systemic administration of the phototumorigenic fluoroquinolone Iomefloxacin photosensitises thymine dimer formation in mouse skin. eScholarID:2d1600
  • Termorshuizen, F., Garssen, J., Norval, M., Koulu, L., Laihia, J., Leino, L., Jansen, C., De Gruijl, F., Gibbs, N., De Simone, C. & Van Loveren, H (2002). A review of studies on the effects of ultraviolet irradiation on the resistance to infections: evidence from rodent infection models and verification by experimental and observational human studies. Int Immunopharmacol, 2(2-3), 263-75. eScholarID:79372 | PMID:11811930

2001

  • Gibbs NK. (2001). Drug-induced skin phototoxicity; lessons from the fluoroquinolones. Sun Protection for Humans&#146. Elsevier Science. eScholarID:3d1067
  • N J Traynor, Gibbs NK. (2001). p53 transactivation photosensitised by the skin phototumorigen Iomefloxacin is not mediated by DNA strand breakage or H202. eScholarID:2d1599

2000

  • Al-Ajmi, H., Dawe, R., Renwick, A., Macklin, B., Ferguson, J. & Gibbs, N (2000). The effect of whole-body sunbed ultraviolet A exposure on the pharmacokinetics of the photolabile drug nifedipine. Photodermatol Photoimmunol Photomed, 16(3), 111-5. eScholarID:79377 | PMID:10885439
  • Blaydes JP, Craig AL, Wallace M, Ball HM, Traynor NJ, Gibbs NK, Hupp TR. (2000). Synergistic activation of p53-dependent transcription by two cooperating damage recognition pathways. Oncogene, 19, 3829-3839. eScholarID:1d3225
  • Blaydes, J., Craig, A., Wallace, M., Ball, H., Traynor, N., Gibbs, N. & Hupp, T (2000). Synergistic activation of p53-dependent transcription by two cooperating damage recognition pathways. Oncogene, 19(34), 3829-39. eScholarID:79376 | PMID:10951576 | DOI:10.1038/sj.onc.1203773
  • Kidd S, Meunier J-R, Traynor NJ, Marrot L, Agapakis-Causse C, Gibbs NK. (2000). The phototumorigenic fluoroquinolone, lomefloxacin, photosensitises p53 accumulation and transcriptional activity in human skin cells. J Photochem Photobiol B:Biol, 58, 26-31. eScholarID:1d3226
  • Kidd, S., Meunier, J., Traynor, N., Marrot, L., Agapakis-Causse, C. & Gibbs, N (2000). The phototumorigenic fluoroquinolone, lomefloxacin, photosensitises p53 accumulation and transcriptional activity in human skin cells. J Photochem Photobiol B, 58(1), 26-31. eScholarID:79373 | PMID:11195849
  • Man, I., Wainwright, N., Gibbs, N. & Ferguson, J (2000). Time course of skin photosensitivity following trimethylpsoralen bath PUVA. Photodermatol Photoimmunol Photomed, 16(5), 211-5. eScholarID:79375 | PMID:11068860
  • Nylander K, Bourdon J-C, Bray SE, Gibbs NK, Kay R, Hart I, Hall PA. (2000). Transcriptional activation of tyrosinase and TRP-1 by p53 links UV irradiation to the protective tanning response. J Pathol, 190, 39-46. eScholarID:1d3227
  • Nylander, K., Bourdon, J., Bray, S., Gibbs, N., Kay, R., Hart, I. & Hall, P (2000). Transcriptional activation of tyrosinase and TRP-1 by p53 links UV irradiation to the protective tanning response. J Pathol, 190(1), 39-46. eScholarID:79379 | PMID:10640990 | DOI:10.1002/(SICI)1096-9896(200001)190:1<39::AID-PATH492>3.0.CO;2-V
  • Spielmann, H., Müller, L., Averbeck, D., Balls, M., Brendler-Schwaab, S., Castell, J., Curren, R., O, d.S., Gibbs, N., Liebsch, M., Lovell, W., Merk, H., Nash, J., Neumann, N., Pape, W., Ulrich, P. & Vohr, H (2000). The second ECVAM workshop on phototoxicity testing. The report and recommendations of ECVAM workshop 42. Altern Lab Anim, 28(6), 777-814. eScholarID:79374 | PMID:11105201
  • Traynor, N., Barratt, M., Lovell, W., Ferguson, J. & Gibbs, N (2000). Comparison of an in vitro cellular phototoxicity model against controlled clinical trials of fluoroquinolone skin phototoxicity. Toxicol In Vitro, 14(3), 275-83. eScholarID:79378 | PMID:10806378

1999

  • Traynor NJ, Gibbs NK. (1999). The phototumorigenic fluoroquinolone lomefloxacin photosensitises pyrimidine dimer formation in human keratinocytes in vitro. Photochem Photobiol, 70, 957-959. eScholarID:1d3224
  • Traynor, N. & Gibbs, N (1999). The phototumorigenic fluoroquinolone lomefloxacin photosensitizes pyrimidine dimer formation in human keratinocytes in vitro. Photochem Photobiol, 70(6), 957-9. eScholarID:79380 | PMID:10628309

1998

  • Garssen, J., Norval, M., el-Ghorr, A., Gibbs, N., Jones, C., Cerimele, D., De Simone, C., Caffieri, S., Dall'Acqua, F., De Gruijl, F., Sontag, Y. & Van Loveren, H (1998). Estimation of the effect of increasing UVB exposure on the human immune system and related resistance to infectious diseases and tumours. J Photochem Photobiol B, 42(3), 167-79. eScholarID:79381 | PMID:9595706

1997

  • Johnson, B., Gibbs, N. & Ferguson, J (1997). Quinolone antibiotic with potential to photosensitize skin tumorigenesis. J Photochem Photobiol B, 37(3), 171-3. eScholarID:79384 | PMID:9085563
  • Reavy, H., Traynor, N. & Gibbs, N (1997). Photogenotoxicity of skin phototumorigenic fluoroquinolone antibiotics detected using the comet assay. Photochem Photobiol, 66(3), 368-73. eScholarID:79382 | PMID:9297980
  • Steerenberg, P., Garssen, J., Dortant, P., van de Vliet, H., Geerse, L., Verlaan, A., Goettsch, W., Sontag, Y., Norval, M., Gibbs, N., Bueno-de-Mesquita, H. & Van Loveren, H (1997). Quercetin prevents UV-induced local immunosuppression, but does not affect UV-induced tumor growth in SKH-1 hairless mice. Photochem Photobiol, 65(4), 736-44. eScholarID:79383 | PMID:9114752

1996

  • Jones, C., Barton, A., Crosby, J., Norval, M. & Gibbs, N (1996). Investigating the red shift between in vitro and in vivo urocanic acid photoisomerization action spectra. Photochem Photobiol, 63(3), 302-5. eScholarID:79386 | PMID:8881334
  • Jones, C., Guckian, M., el-Ghorr, A., Gibbs, N. & Norval, M (1996). Effects of phototherapy on the production of cytokines by peripheral blood mononuclear cells and on systemic antibody responses in patients with psoriasis. Photodermatol Photoimmunol Photomed, 12(5), 204-10. eScholarID:79385 | PMID:9112279

1995

  • Gibbs, N., Traynor, N., MacKie, R., Campbell, I., Johnson, B. & Ferguson, J (1995). The phototumorigenic potential of broad-band (270-350 nm) and narrow-band (311-313 nm) phototherapy sources cannot be predicted by their edematogenic potential in hairless mouse skin. J Invest Dermatol, 104(3), 359-63. eScholarID:79390 | PMID:7861002
  • Guckian, M., Jones, C., Vestey, J., Cooper, E., Dawe, R., Gibbs, N. & Norval, M (1995). Immunomodulation at the initiation of phototherapy and photochemotherapy. Photodermatol Photoimmunol Photomed, 11(4), 163-9. eScholarID:79387 | PMID:8850250
  • Norval, M., Gibbs, N. & Gilmour, J (1995). The role of urocanic acid in UV-induced immunosuppression: recent advances (1992-1994). Photochem Photobiol, 62(2), 209-17. eScholarID:79388 | PMID:7480130

1994

  • Applegate, L., Frenk, E., Gibbs, N., Johnson, B., Ferguson, J. & Tyrrell, R (1994). Cellular sensitivity to oxidative stress in the photosensitivity dermatitis/actinic reticuloid syndrome. J Invest Dermatol, 102(5), 762-7. eScholarID:79418 | PMID:8176261
  • Chadwick, R., Traynor, N., Moseley, H. & Gibbs, N (1994). Blue light curing units--a dermatological hazard? Br Dent J, 176(1), 17-21. eScholarID:79417 | PMID:8312065

1993

  • Bilsland, D., George, S., Gibbs, N., Aitchison, T., Johnson, B. & Ferguson, J (1993). A comparison of narrow band phototherapy (TL-01) and photochemotherapy (PUVA) in the management of polymorphic light eruption. Br J Dermatol, 129(6), 708-12. eScholarID:79391 | PMID:8286256
  • Gibbs, N., Norval, M., Traynor, N., Crosby, J., Lowe, G. & Johnson, B (1993). Comparative potency of broad-band and narrow-band phototherapy sources to induce edema, sunburn cells and urocanic acid photoisomerization in hairless mouse skin. Photochem Photobiol, 58(5), 643-7. eScholarID:79392 | PMID:8284319
  • Gibbs, N., Norval, M., Traynor, N., Wolf, M., Johnson, B. & Crosby, J (1993). Action spectra for the trans to cis photoisomerisation of urocanic acid in vitro and in mouse skin. Photochem Photobiol, 57(3), 584-90. eScholarID:79393 | PMID:8475193

1992

  • Bilsland D, Diffey BL, Farr PM, Ferguson J, Gibbs NK, Hawk JL, Johnson BE, Magnus IA, Moseley H, Murphy GM, et al. (1992). Diagnostic phototesting in the United Kingdom. Br J Dermatol, 127(3), 297-9. eScholarID:79415
  • Gibbs, N., Traynor, N., Johnson, B. & Ferguson, J (1992). In vitro phototoxicity of nifedipine: sequential induction of toxic and non-toxic photoproducts with UVA radiation. J Photochem Photobiol B, 13(3-4), 275-88. eScholarID:79394 | PMID:1506992

1990

  • Diffey BL, Farr PM, Ferguson J, Gibbs NK, deGruijl FR, Hawk JL, Johnson BE, Lowe G, Mackie RM, McKinlay AF, et al. (1990). Tanning with ultraviolet A sunbeds. BMJ, 301(6755), 773-4. eScholarID:79416

1989

  • Baydoun, S., Gibbs, N. & Young, A (1989). Action spectra and chromophores for lethal photosensitization of Candida albicans by DNA monoadducts formed by 8-methoxypsoralen and monofunctional furocoumarins. Photochem Photobiol, 50(6), 753-61. eScholarID:79395 | PMID:2696990
  • Black, H., Young, A. & Gibbs, N (1989). Effects of butylated hydroxytoluene upon PUVA-tumorigenesis and induction of ornithine decarboxylase activity in the mouse. J Photochem Photobiol B, 3(1), 91-100. eScholarID:79396 | PMID:2498483

1988

  • Gibbs, N., Quanten, E., Baydoun, S., Knox, C., Roelandts, R., de Schryver, F., Truscott, T. & Young, A (1988). Photophysical, photochemical and photobiological properties of pyrrolocoumarins; a new class of photoactive compounds. J Photochem Photobiol B, 2(1), 109-22. eScholarID:79397 | PMID:3149297

1987

  • Gibbs, N (1987). An adaptation of the Candida albicans phototoxicity test to demonstrate photosensitizer action spectra. Photodermatol, 4(6), 312-6. eScholarID:79399 | PMID:3328174
  • Young, A., Gibbs, N. & Magnus, I (1987). Modification of 5-methoxypsoralen phototumorigenesis by UVB sunscreens: a statistical and histologic study in the hairless albino mouse. J Invest Dermatol, 89(6), 611-7. eScholarID:79398 | PMID:3680986

1986

  • Garmyn, M., Murphy, G., Gibbs, N. & Hawk, J (1986). Are the protection factors assigned to proprietory sunscreen products misleading? Photodermatol, 3(2), 104-6. eScholarID:79400 | PMID:3703711
  • Gibbs NK, Hönigsmann H, Young AR. (1986). PUVA treatment strategies and cancer risk. Lancet, 8473(1), 150-1. eScholarID:79413

1985

  • Gibbs, N., Young, A. & Magnus, I (1985). A strain of hairless mouse susceptible to tumorigenesis by TPA alone: studies with 8-methoxypsoralen and solar simulated radiation. Carcinogenesis, 6(5), 797-9. eScholarID:79402 | PMID:4006065
  • Gibbs, N., Young, A. & Magnus, I (1985). Failure of UVR dose reciprocity for skin tumorigenesis in hairless mice treated with 8-methoxypsoralen. Photochem Photobiol, 42(1), 39-42. eScholarID:79401 | PMID:4059357

1984

  • Gibbs, N., Young, A. & Corbett, M (1984). Personal solar UVR exposure: a method of increasing the reliability of measurements made with film badge dosimeters. Photodermatol, 1(3), 133-6. eScholarID:79403 | PMID:6527954

1983

  • Gibbs, N. & Young, A (1983). An evaluation of nalidixic acid film as a UV-A radiation dosimeter. Photochem Photobiol, 37(3), 345-8. eScholarID:79404 | PMID:6844427

Top of page