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School of Medicine

Professor Paul Brenchley PhD

Honorary Professor of Renal Immunology

Renal Research Labs
Manchester Institute of Nephrology & Transplantation
Manchester Royal Infirmary
Oxford Road
Manchester M13 9WL

 

Role

Prof Brenchley is head of the renovascular biology research group in Cardiovascular Research. He directs the renal research labs and coordinates research for the Manchester Institute of Nephrology & Transplantation based at Manchester Royal Infirmary. He is currently chair of ReGeNet, the European Renal Genome Network.

 

Research

The renovascular biology research group is concerned with translating knowledge gained from researching mechanisms of kidney disease and comorbidities into novel therapies for the benefit of patients. The group has interests in

a) preserving native kidney function and preventing progression of chronic kidney disease (CKD)

In this area we are investigating the nephrotic syndrome, in particular, mechanisms of proteinuria in membranous nephropathy, minimal change disease and FSGS. We are describing the genetic contribution to progression to CKD and have specific projects focused on SLE nephritis and ANCA Vasculitis

b) improving dialysis modalities and reducing the comorbidities of dialysis

As part of GENECURE (EUFP6), we are linked with nine other European renal centres focussing on the cardiovascular phenotype and genotype linked to accelerated atherosclerosis in uremia. As part of UK EPS network, we are investigating the role of fibrosis and angiogenesis in ultrafiltration failure and encapsulating peritoneal sclerosis (EPS) which can be a problem in some patients on peritoneal dialysis. We are interested in developing novel forms of dialysis and improving imaging technologies for evaluating the structure and function of arteriovenous fistulas and the peritoneal membrane.

c) improving outcomes for kidney and pancreas transplantation

The shortage of organs for transplantation means many patients cannot benefit from this therapy. We are exploring stem cell based models for regenerating kidney and pancreas tissue for transplantation. Ischaemia reperfusion injury can damage organs in the early post transplant period and is linked with a poorer outcome. We are conducting a clinical trial of high dose EPO for the possible prevention of such damage. Longer term, chronic allograft nephropathy and cardiovascular comorbidity remain the challenges to overcome and we are investigating the genetic background to long and short term survival.

 

Qualifications

B.Sc. 1971; University of Birmingham

Ph.D. 1975; University of Manchester

 

Collaborators and affiliated staff

Collaborators

In Manchester

  • Prof John Aplin, Dept of Obstetrics & Gynaecology, Univ of Manchester
  • Dr Ian Bruce, ARC Unit, Univ of Manchester
  • Dr Mark Dickinson, Photon Science Institute, Univ of Manchester
  • Prof Gordon Jayson, Department of Medical Oncology, Christie Hospital
  • Dr Ian Hampson, Dept of Obstetrics and Gynaecology, Univ of Manchester
  • Dr Philip Kalra, Dept of Renal Medicine, Salford Royal Hospitals
  • Dr Edward McKenzie, Faculty of Life Sciences, Univ of Manchester
  • Dr Rein Ulijn, Biomaterials Dept, MIB, Univ of Manchester
  • Dr Nick Webb, Dept of Paediatric Nephrology, CMMC

In UK

  • Prof Simon Davies, Dept of Renal Medicine, Univ of Keele
  • Professor P Mathieson, Academic Renal Unit, University of Bristol
  • Dr IS Roberts, John Radcliffe Infirmary, Oxford
  • Dr Martin Wilkie, Dept of Renal Medicne, Sheffield

International

  • Dr Els Boeschoten, Hans Mak Institute, Amsterdam
  • Dr A Chandraker, Department of Nephrology, Harvard Medical School
  • Prof Bengt Lindholm, Dept of Nephrology, Karolinska University
  • Prof Gerjan Navis, Dept of Nephrology, Univ of Groningen
  • Prof Pierre Ronco, Hopital Tenon, Paris
 

Publications

2011

  • Wright, B., Fenner, J., Summers, A., Hutchinson, C., Hurst, H., Wilkie, M., Herrick, S., Brenchley, P., Gillott, R., Spencer, P., Augustine, T. & Bardhan, K (2011). TOWARDS DETECTING THE 'ADHESIVE COCOON' OF ENCAPSULATING PERITONEAL SCLEROSIS (EPS) BY CINE-MRI: A PILOT STUDY. eScholarID:127438
  • Ebah, L., Brenchley, P., Coupes, B. & Mitra, S (2011). A Modified in vivo Flow Variation Technique of Microdialysis for Sampling Uremic Toxins in the Subcutaneous Interstitial Compartment. BLOOD PURIFICATION, 32(2), 96-103. eScholarID:127436 | DOI:10.1159/000324207
  • Hutchison, A., Smith, C. & Brenchley, P (2011). Pharmacology, efficacy and safety of oral phosphate binders. Nat Rev Nephrol, 7(10), 578-89. eScholarID:150286 | PMID:21894188 | DOI:10.1038/nrneph.2011.112
  • Stanescu, H., Arcos-Burgos, M., Medlar, A., Bockenhauer, D., Kottgen, A., Dragomirescu, L., Voinescu, C., Patel, N., Pearce, K., Hubank, M., Stephens, H., Laundy, V., Padmanabhan, S., Zawadzka, A., Hofstra, J., Coenen, M., den Heijer, M., Kiemeney, L., Bacq-Daian, D., Stengel, B., Powis, S., Brenchley, P., Feehally, J., Rees, A., Debiec, H., Wetzels, J., Ronco, P., Mathieson, P. & Kleta, R (2011). Risk HLA-DQA1 and PLA(sub 2)R1 Alleles in Idiopathic Membranous Nephropathy. NEW ENGLAND JOURNAL OF MEDICINE, 364(7), 616-626. eScholarID:127434 | DOI:10.1056/NEJMoa1009742
  • Wright, B., Summers, A., Fenner, J., Gillott, R., Hutchinson, C., Spencer, P., Wilkie, M., Hurst, H., Herrick, S., Brenchley, P., Augustine, T. & Bardhan, K (2011). INITIAL OBSERVATIONS USING A NOVEL "CINE" MAGNETIC RESONANCE IMAGING TECHNIQUE TO DETECT CHANGES IN ABDOMINAL MOTION CAUSED BY ENCAPSULATING PERITONEAL SCLEROSIS. PERITONEAL DIALYSIS INTERNATIONAL, 31(3), 287-290. eScholarID:127433 | DOI:10.3747/pdi.2010.00078

2010

  • de Freitas, D., Coupes, B., Hoyle, D., Read, I., Riad, H., Brenchley, P. & Picton, M (2010). Effect of High Dose Erythropoietin on Early Graft Outcomes in NHBD and ECD Kidney Recipients: A Randomised, Placebo-Controlled Trial. eScholarID:127441
  • Vardhan, A., Khattar, R., Brenchley, P. & Hutchison, A (2010). The significance of minimally elevated cardiac troponin-T levels in predicting cardiovascular events & sudden death in clinically well patients with end-stage chronic kidney disease. eScholarID:127444

2009

  • Dhaygude, A., Harris, S., Ebah, L., Bruce, I., O'Donoghue, D., Kalra, P., Venning, M. & Brenchley, P (2009). Differential cytokine expression in pANCA- and cANCA-associated vasculitis. eScholarID:127440
  • Ogundare, O., Dhaygude, A., Ande, P., Harris, S., Bruce, I., Kalra, P., Venning, M. & Brenchley, P (2009). Increased incidence of venous thromboembolism in ANCA-associated systemic vasculitis. eScholarID:127442

2008

  • de Freitas, D., Coupes, B., Picton, M., Greener, I., Tellez, J. & Brenchley, P (2008). Erythropoeitin modulates apoptosis related gene expression in human microvascular endothelial and renal tubular epithelial cells. eScholarID:127439
  • Harris LK, Baker PN, Brenchley PEC, Aplin JD. (2008). Trophoblast-derived heparanase is not required for invasion. Placenta, 29, eScholarID:1d17117

2007

  • Harris S, Coupes BM, Roberts SA, Roberts ISD, Short CC, Brenchley PEC. (2007). Persistant plasma transforming growth factor beta 1 is linked to the development of chronic allograft nephropathy following renal transplantation. Journal of Nephrology, 20, 177-185. eScholarID:1d15570
  • Jordaan A, de Freitas D, Hurst H, Alderdice J, Curwell J, Brenchley PEC, Hutchison A, Summers A. (2007). Malnutrition and refeeding syndrome associated with encapsulating peritoneal sclerosis. Perit Dial Int, 27( 1), 100-1. eScholarID:1d31858
  • Ralph S, Brenchley PEC, Summers A, Rosa D, Swindell R, Jayson G. (2007). Heparanase gene haplotype (CGC) is associated with stage of disease in patients with ovarian carcinoma. Cancer Sci, 98( 6), 844-9. eScholarID:1d16990
  • Seminara, D, Khoury, M, O'Brien, T, Manolio, T, Gwinn, M, Little, J, Higgins, J, Bernstein, J, Boffetta, P, Bondy, M, Bray, M, Brenchley, PEC, Buffler, P, Casas, J, Chokkalingam, A, Danesh, J, Davey Smith, G, Dolan, S, Duncan, R, Gruis, N, Hashibe, M, Hunter, D, Jarvelin, M, Malmer, B, Maraganore, D, Newton-Bishop, J, Riboli, E, Salanti, G, Taioli, E, Timpson, N, Uitterlinden, A, Vineis, P, Wareham, N, Winn, D, Zimmern, R, Ioannidis, J, NULL, NULL. (2007). The emergence of networks in human genome epidemiology: challenges and opportunities. Epidemiology, 18( 1), 1-8. eScholarID:1d31775

2006

  • Gbadegesin R, Cotton S, Watson C, Brenchley PEC, Webb N. (2006). Association between ICAM-1 Gly-Arg polymorphism and renal parenchymal scarring following childhood urinary tract infection. Int J Immunogenet, 33( 1), 49-53. eScholarID:1d13267
  • Jackson M, Ahmad Y, Bruce IN, Bruce IN, Coupes B, Brenchley PEC. (2006). Activation of transforming growth factor-beta1 and early atherosclerosis in systemic lupus erythematosus. Arthritis Res Ther, 8( 3), eScholarID:1d13266
  • Young, H, Angela M Summers, Ian Read, David A Fairhurst, Plant, D, Emanuela Campalani, Catherine H Smith, Jonathan NWN Barker, Michael J Detmar, Brenchley, PEC, Griffiths, CEM. (2006). Interaction between genetic control of vascular endothelial growth factor production and retinoid responsiveness in psoriasis. Journal of investigative dermatology, 126, 453-459. eScholarID:1d26801 | DOI:10.1038/sj.jid.5700096
  • Brenchley PEC, Lindholm B, Dekker FW, Navis G. (2006). Translating knowledge of the human genome into clinical practice in nephrology dialysis and transplantation: the renal genome network (ReGeNet). Nephrology, Dialysis and Transplantation, 21 (10), 2681-3. eScholarID:17d489
  • Ioannidis, J, Gwinn, M, Little, J, Higgins, J, Bernstein, J, Boffetta, P, Bondy, M, Bray, M, Brenchley, PEC, Buffler, P, Casas, J, Chokkalingam, A, Danesh, J, Smith, G, Dolan, S, Duncan, R, Gruis, N, Hartge, P, Hashibe, M, Hunter, D, Jarvelin, M, Malmer, B, Maraganore, D, Newton-Bishop, J, O'Brien, T, Petersen, G, Riboli, E, Salanti, G, Seminara, D, Smeeth, L, Taioli, E, Timpson, N, Uitterlinden, A, Vineis, P, Wareham, N, Winn, D, Zimmern, R, Khoury, M, NULL. (2006). A road map for efficient and reliable human genome epidemiology. Nat Genet, 38( 1), 3-5. eScholarID:17d314
  • Summers AM, Brenchley PEC. (2006). An international encapsulating peritoneal sclerosis registry and DNA bank: why we need one now. Perit. Dial. Int, 26(5), 559-63. eScholarID:17d880

2005

  • Agrawal, A., Coupes, B., McWilliam, L., Brierley, J., Riad, H. & Brenchley, P (2005). Ischaemia/reperfusion injury in renal allografts differentially modulates VEGF and HGF. eScholarID:127443
  • Holt R, Webb N, Ralph S, Davies J, Short C, Brenchley PEC. (2005). Heparanase activity is dysregulated in children with steroid-sensitive nephrotic syndrome. Kidney Int, 67( 1), 122-9. eScholarID:1d13273
  • Marshall D, Clancy M, Bottomley M, Symonds K, Brenchley PEC, Bravery C. (2005). Transplantation of metanephroi to sites within the abdominal cavity. Transplant Proc, 37( 1), 194-7. eScholarID:1d13272
  • Summers A, Coupes B, Brennan M, Ralph S, Short C, Brenchley PEC. (2005). VEGF -460 genotype plays an important role in progression to chronic kidney disease stage 5. Nephrol Dial Transplant, 20( 11), 2427-32. eScholarID:1d13269
  • Summers, A, Clancy, M, Syed, F, Harwood, N, Brenchley, PEC, Augustine, T, Riad, H, Hutchison, A, Taylor, P, Pearson, R, Gokal, R. (2005). Single-center experience of encapsulating peritoneal sclerosis in patients on peritoneal dialysis for end-stage renal failure. Kidney Int, 68( 5), 2381-8. eScholarID:1d13268

2004

  • He X, Brenchley PEC, Jayson G-, Hampson L, Davies JM, Hampson IN. (2004). Hypoxia increases heparanase dependent tumor cell invasion which can be inhibited by anti-heparanase antibodies. Cancer Res, 64(11), 3928-33. eScholarID:1d10169 | DOI:10.1158/0008-5472.CAN-03-2718
  • Holt R, Webb NJ.A, Ralph SSA, Davies J, Short CC, Brenchley PEC. (2004). Heparanase activity is dysregulated in children with steroid-sensitive nephrotic syndrome. Kidney International, 67, 122-129. eScholarID:1d26162
  • Ray DW, Mishra M, Ralph S, Read I, Davies R, Brenchley P. (2004). Association of the VEGF gene with proliferative diabetic retinopathy but not proteinuria in diabetes. Diabetes, 53, 861-864. eScholarID:1d19278
  • Webb N, Brenchley PEC. (2004). Cytokines and cell adhesion molecules in the inflammatory response during acute pyelonephritis. Nephron Exp Nephrol, 96, e1-6. eScholarID:1d26157
  • Xiaotong HE, Brenchley PEC, Jayson G-, Hampson L, Davies J, Hampson IN. (2004). Hypoxia increases heparanase dependent tumour cell invasion which can be inhibited by anti-heparanase antibodies. Cancer Research, eScholarID:1d26158
  • Young H, Summers AM, Bhushan M, Brenchley PEC, Griffiths CEM. (2004). Single-Nucleotide Polymorphisms of Vascular Endothelial Growth Factor (VEGF) in Psoriasis of Early Onset. Journal of Investigative Dermatology, 122, 209-215. eScholarID:1d7611 | DOI:10.1046/j.0022-202X.2003.22107.x

1997

  • ISD Roberts, Farrington CC, M Dziobon, Brenchley PEC, Short CC, Canfield AE. (1997). Thrombospondin-1 expression in renal allograft rejection. Journal Of Pathology, 181, A53. eScholarID:17d588

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