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Dr Riina Rautemaa-Richardson D.D.S., PhD, FRCPath

Photograph of Riina Rautemaa-Richardson

Senior Clinical Research Fellow

Respiratory Research Group
School of Translational Medicine
Education and Research Centre
Wythenshawe Hospital
Southmoor Road
Manchester
M23 9LT
UK

 

Role

Senior Clinical Research Fellow in Infectious Diseases with an honorary Consultancy at the University Hospital of South Manchester

 

Memberships of Committees and Professional Bodies

Royal College of Pathologists, European Society for Clinical Microbiology and Infectious Diseases, International Society for Human and Animal Mycology, Association of Clinical Oral Microbiology, International Association for Dental Research, British Society for Medical Mycology, British Society for Oral Medicine, Finnish Dental Association, Finish Society for Hospital Hygiene, Finnish Society for Immunology, Finnish Society for the Research of Infectious Diseases

Research

My aim is to advance our understanding of the interplay between upper respiratory tract microbes and the host.
My main research interests include local and systemic infection complications of oral source, oral and upper respiratory tract infections in immunocompromised patients, host-microbe interactions, biofilms, antimicrobial susceptibility and treatment of respiratory tract pathogens, carcinogenicity of chronic mucosal infections, biomaterial infections and infection control. My group (8 PhD students and a post doctoral fellow) undertakes basic research (genomics, pathogenesis and mechanisms of antimicrobial drug resistance and carcinogenicity of microbial acetaldehyde production), applied laboratory work (models of pathogenesis, molecular diagnostics, antifungal resistance testing, pharmacodynamics of new antimicrobials), and clinical studies (tissue response to chronic oral infection and acetaldehyde exposure).

 

Teaching

I have taught Clinical Microbiology and Immunology since 1997 first as a Clinical Assistant and more recently as a Senior Lecturer. I have trained registrars in clinical microbiology and infectious diseases from the Departments of Maxillo-Facial Surgery, Clinical Dentistry, Medicine and Infectious Diseases, Otorhinolaryngology and Clinical Microbiology since 2005. I was nominated the lecturer of the year (Oral medicine) and the CME trainer of the year (Finnish Dental Association) in 2008. I am also active in post graduate research supervision and have 8 PhD students.

 

Biography

I started as a Senior Clinical Research Fellow in Infectious Diseases with an honorary Consultancy at the University Hospital of South Manchester in July 2009. Prior to these positions I was the Senior Lecturer and Consultant in Oral Medicine, Oral Microbiology and Infectious diseases at the University of Helsinki and the University Hospital of Helsinki, Finland. I completed my PhD on innate mucosal immunology in 2001 after which I completed a specialist training program in Medical Microbiology.

I am a clinician with expertise in oral disease and health and in infectious diseases. My group (8 PhD students and a post doctoral fellow) undertakes basic research (genomics, pathogenesis and mechanisms of antimicrobial drug resistance and carcinogenicity of microbial acetaldehyde production), applied laboratory work (models of pathogenesis, molecular diagnostics, antifungal resistance testing, pharmacodynamics of new antimicrobials), and clinical studies (tissue response to chronic oral infection and acetaldehyde exposure). I described a novel immune evasion mechanism for gram negative bacteria in 2001 and I was first to publish that one of the major pathogens in chronic periodontitis, Porphyromonas gingivalis can cause an intracellular infection in the oral epithelia. I was also the first to describe the carcinogenicity of chronic oral candidal infection in APECED patients and that the production of carcinogenic acetaldehyde from dietary sugars and alcohol could partially explain this (Int J Cancer 2009, 2011). I have published a number of papers on the development of antifungal resistance in Candida albicans in APECED patients (JAC 2007, 2010). In addition, I have produced systematic data on severe odontogenic infections and their risk factors (J Infect 2008). To date I have published a total of 60 peer-reviewed articles and books or book chapters in the field of microbiology, mucosal immunology, infectious diseases and oral medicine. I am also an awarded teacher with a diploma in University education and I was recently awarded a diploma in infection control.

 

Qualifications

 DDS, PhD, FRCPath

 

Publications

2011

  • Bagabir, R., Syed, F., Rautemaa, R., McGrouther, D., Paus, R. & Bayat, A (2011). Upregulation of Toll-Like Receptors (TLRs) 6, 7, and 8 in Keloid Scars. J Invest Dermatol, 131(10), 2128-30. eScholarID:130896 | PMID:21677671 | DOI:10.1038/jid.2011.163
  • Ramage, G., Jose, A., Coco, B., Rajendran, R., Rautemaa, R., Murray, C., Lappin, D. & Bagg, J (2011). Commercial mouthwashes are more effective than azole antifungals against Candida albicans biofilms in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 111(4), 456-60. eScholarID:130895 | PMID:21310633 | DOI:10.1016/j.tripleo.2010.10.043
  • Rautemaa, R. & Ramage, G (2011). Oral candidosis- Clinical challenges of a biofilm disease. Crit Rev Microbiol, eScholarID:130894 | PMID:21777047 | DOI:10.3109/1040841X.2011.585606
  • Seppänen, L., Lemberg, K., Lauhio, A., Lindqvist, C. & Rautemaa, R (2011). Is dental treatment of an infected tooth a risk factor for locally invasive spread of infection? J Oral Maxillofac Surg, 69(4), 986-93. eScholarID:126509 | PMID:20950917 | DOI:10.1016/j.joms.2010.05.015
  • Siikala, E., Bowyer, P., Richardson, M., Saxen, H., Sanglard, D. & Rautemaa, R (2011). ADH1 expression inversely correlates with CDR1 and CDR2 in Candida albicans from chronic oral candidosis in APECED (APS-I) patients. FEMS Yeast Res, 11(6), 494-498. eScholarID:130892 | PMID:21585651 | DOI:10.1111/j.1567-1364.2011.00739.x

2010

  • Levon, J., Myllymaa, K., Kouri, V., Rautemaa, R., Kinnari, T., Myllymaa, S., Konttinen, Y. & Lappalainen, R (2010). Patterned macroarray plates in comparison of bacterial adhesion inhibition of tantalum, titanium, and chromium compared with diamond-like carbon. J Biomed Mater Res A, 92(4), 1606-13. eScholarID:130897 | PMID:19437436 | DOI:10.1002/jbm.a.32486
  • Seppänen, L., Rautemaa, R., Lindqvist, C. & Lauhio, A (2010). Changing clinical features of odontogenic maxillofacial infections. Clin Oral Investig, 14(4), 459-65. eScholarID:130900 | PMID:19449042 | DOI:10.1007/s00784-009-0281-5
  • Siikala, E., Rautemaa, R., Richardson, M., Saxen, H., Bowyer, P. & Sanglard, D (2010). Persistent Candida albicans colonization and molecular mechanisms of azole resistance in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) patients. J Antimicrob Chemother, 65(12), 2505-13. eScholarID:126531 | PMID:20876623 | DOI:10.1093/jac/dkq354

2009

  • Husebye, E., Perheentupa, J., Rautemaa, R. & Kämpe, O (2009). Clinical manifestations and management of patients with autoimmune polyendocrine syndrome type I. J Intern Med, 265(5), 514-29. eScholarID:126520 | PMID:19382991 | DOI:10.1111/j.1365-2796.2009.02090.x
  • Nieminen, M., Uittamo, J., Salaspuro, M. & Rautemaa, R (2009). Acetaldehyde production from ethanol and glucose by non-Candida albicans yeasts in vitro. Oral Oncol, 45(12), e245-8. eScholarID:126503 | PMID:19793674 | DOI:10.1016/j.oraloncology.2009.08.002
  • Richardson, M. & Rautemaa, R (2009). How the host fights against Candida infections. Front Biosci (Schol Ed), 1(1), 246-57. eScholarID:79116 | PMID:19482700 | DOI:10.2741/3533
  • Richardson, M. & Rautemaa, R (2009). How the host fights against Candida infections. Front Biosci, 14(1), 4363-75. eScholarID:79120 | PMID:19273355 | DOI:10.2741/3533
  • Rusanen, P., Siikala, E., Uittamo, J., Richardson, M. & Rautemaa, R (2009). A novel method for sampling the microbiota from the oral mucosa. Clin Oral Investig, 13(2), 243-6. eScholarID:126508 | PMID:18797939 | DOI:10.1007/s00784-008-0225-5
  • Siikala E, Richardson M, Pfaller MA, Diekema DJ, Messer S, Perheentupa J, Saxén H, Rautemaa R. (2009). Candida albicans isolates from APECED patients show decreased susceptibility to miconazole and ketoconazole. Int J Antimicrob Agents, 34, 607-609. eScholarID:79165

2008

  • Beklen, A., Hukkanen, M., Richardson, R. & Konttinen, Y (2008). Immunohistochemical localization of Toll-like receptors 1-10 in periodontitis. Oral Microbiol Immunol, 23(5), 425-31. eScholarID:79147 | PMID:18793367 | DOI:10.1111/j.1399-302X.2008.00448.x
  • Beklen, A., Pihakari, A., Rautemaa, R., Hietanen, J., Ali, A. & Konttinen, Y (2008). Chronic sinusitis associated with the use of unrecognized bone substitute: a case report. Quintessence Int, 39(5), 401-5. eScholarID:126532 | PMID:19088954
  • Rautemaa, R., Richardson, M., Pfaller, M., Perheentupa, J. & Saxén, H (2008). Activity of amphotericin B, anidulafungin, caspofungin, micafungin, posaconazole, and voriconazole against Candida albicans with decreased susceptibility to fluconazole from APECED patients on long-term azole treatment of chronic mucocutaneous candidiasis. Diagn Microbiol Infect Dis, 62(2), 182-5. eScholarID:126505 | PMID:18597968 | DOI:10.1016/j.diagmicrobio.2008.05.007
  • Rautemaa, R., Richardson, M., Pfaller, M., Perheentupa, J. & Saxen, H (2008). Reduction of fluconazole susceptibility of Candida albicans in APECED patients due to long-term use of ketoconazole and miconazole. Scand J Infect Dis, 40(11-12), 904-7. eScholarID:126537 | PMID:18651265 | DOI:10.1080/00365540802275853
  • Seppänen, L., Lauhio, A., Lindqvist, C., Suuronen, R. & Rautemaa, R (2008). Analysis of systemic and local odontogenic infection complications requiring hospital care. J Infect, 57(2), 116-22. eScholarID:126506 | PMID:18649947 | DOI:10.1016/j.jinf.2008.06.002

2007

  • Ali, A., Rautemaa, R., Hietanen, J., Beklen, A. & Konttinen, Y (2007). A possible CD1a Langerhans cell-mast cell interaction in chronic hyperplastic candidosis. J Oral Pathol Med, 36(6), 329-36. eScholarID:126536 | PMID:17559493 | DOI:10.1111/j.1600-0714.2007.00527.x
  • Kurkivuori, J., Salaspuro, V., Kaihovaara, P., Kari, K., Rautemaa, R., Grönroos, L., Meurman, J. & Salaspuro, M (2007). Acetaldehyde production from ethanol by oral streptococci. Oral Oncol, 43(2), 181-6. eScholarID:126527 | PMID:16859955 | DOI:10.1016/j.oraloncology.2006.02.005
  • Maijala, M., Rautemaa, R., Järvensivu, A., Richardson, M., Salo, T. & Tjäderhane, L (2007). Candida albicans does not invade carious human dentine. Oral Dis, 13(3), 279-84. eScholarID:126529 | PMID:17448209 | DOI:10.1111/j.1601-0825.2006.01279.x
  • Rautemaa, R., Hietanen, J., Niissalo, S., Pirinen, S. & Perheentupa, J (2007). Oral and oesophageal squamous cell carcinoma--a complication or component of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED, APS-I). Oral Oncol, 43(6), 607-13. eScholarID:126530 | PMID:16997613 | DOI:10.1016/j.oraloncology.2006.07.005
  • Rautemaa, R., Lauhio, A., Cullinan, M. & Seymour, G (2007). Oral infections and systemic disease--an emerging problem in medicine. Clin Microbiol Infect, 13(11), 1041-7. eScholarID:126507 | PMID:17714525 | DOI:10.1111/j.1469-0691.2007.01802.x
  • Rautemaa, R., Richardson, M., Pfaller, M., Koukila-Kähkölä, P., Perheentupa, J. & Saxén, H (2007). Decreased susceptibility of Candida albicans to azole antifungals: a complication of long-term treatment in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) patients. J Antimicrob Chemother, 60(4), 889-92. eScholarID:126518 | PMID:17704513 | DOI:10.1093/jac/dkm299

2006

  • Richardson M, Rautemaa R, Hietanen J. (2006). Diagnosis of Candida infection in tissue by immunohistochemistry. In K. Kavanagh (Ed.), Medial Mycology: Cellular and Molecular Techniques. Chichester: John Wiley & Sons. eScholarID:79150
  • Ali, A., Rautemaa, R., Hietanen, J., Järvensivu, A., Richardson, M. & Konttinen, Y (2006). Expression of interleukin-8 and its receptor IL-8RA in chronic hyperplastic candidosis. Oral Microbiol Immunol, 21(4), 223-30. eScholarID:126515 | PMID:16842506 | DOI:10.1111/j.1399-302X.2006.00280.x
  • He, X., Meurman, J., Kari, K., Rautemaa, R. & Samaranayake, L (2006). In vitro adhesion of Candida species to denture base materials. Mycoses, 49(2), 80-4. eScholarID:126528 | PMID:16466438 | DOI:10.1111/j.1439-0507.2006.01189.x
  • Järvensivu, A., Rautemaa, R., Sorsa, T. & Richardson, M (2006). Specificity of the monoclonal antibody 3H8 in the immunohistochemical identification of Candida species. Oral Dis, 12(4), 428-33. eScholarID:126521 | PMID:16792731 | DOI:10.1111/j.1601-0825.2006.01228.x
  • Rautemaa, R., Nordberg, A., Wuolijoki-Saaristo, K. & Meurman, J (2006). Bacterial aerosols in dental practice - a potential hospital infection problem? J Hosp Infect, 64(1), 76-81. eScholarID:126514 | PMID:16820249 | DOI:10.1016/j.jhin.2006.04.011
  • Rautemaa, R., Rusanen, P., Richardson, M. & Meurman, J (2006). Optimal sampling site for mucosal candidosis in oral cancer patients is the labial sulcus. J Med Microbiol, 55(Pt 10), 1447-51. eScholarID:126535 | PMID:17005796 | DOI:10.1099/jmm.0.46615-0

2005

  • Ali, A., Niissalo, S., Hietanen, J., Laine, M., Rautemaa, R. & Konttinen, Y (2005). Expression of alpha-defensin-1 in chronic hyperplastic candidosis. J Oral Pathol Med, 34(6), 347-51. eScholarID:126523 | PMID:15946182 | DOI:10.1111/j.1600-0714.2005.00317.x

2004

  • Järvensivu, A., Hietanen, J., Rautemaa, R., Sorsa, T. & Richardson, M (2004). Candida yeasts in chronic periodontitis tissues and subgingival microbial biofilms in vivo. Oral Dis, 10(2), 106-12. eScholarID:126525 | PMID:14996281
  • Rautemaa, R., Järvensivu, A., Kari, K., Wahlgren, J., DeCarlo, A., Richardson, M. & Sorsa, T (2004). Intracellular localization of Porphyromonas gingivalis thiol proteinase in periodontal tissues of chronic periodontitis patients. Oral Dis, 10(5), 298-305. eScholarID:126524 | PMID:15315648 | DOI:10.1111/j.1601-0825.2004.01021.x

2002

  • Rautemaa, R., Helander, T. & Meri, S (2002). Herpes simplex virus 1 infected neuronal and skin cells differ in their susceptibility to complement attack. Immunology, 106(3), 404-11. eScholarID:126516 | PMID:12100729

2001

  • Rautemaa, R., Rautelin, H., Puolakkainen, P., Kokkola, A., Kärkkäinen, P. & Meri, S (2001). Survival of Helicobacter pylori From complement lysis by binding of GPI-anchored protectin (CD59). Gastroenterology, 120(2), 470-9. eScholarID:126513 | PMID:11159887

1999

  • Rautemaa, R. & Meri, S (1999). Complement-resistance mechanisms of bacteria. Microbes Infect, 1(10), 785-94. eScholarID:126511 | PMID:10816084

1998

  • Rautemaa, R., Jarvis, G., Marnila, P. & Meri, S (1998). Acquired resistance of Escherichia coli to complement lysis by binding of glycophosphoinositol-anchored protectin (CD59). Infect Immun, 66(5), 1928-33. eScholarID:126533 | PMID:9573071

1996

  • Rautemaa, R. & Meri, S (1996). Protection of gingival epithelium against complement-mediated damage by strong expression of the membrane attack complex inhibitor protectin (CD59). J Dent Res, 75(1), 568-74. eScholarID:126512 | PMID:8655761

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