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School of Medicine

Dr Sarah Herrick PhD

Lecturer

School of Translational Medicine, Faculty of Medical and Human Sciences, University of Manchester, 3.106 Stopford Building, Oxford Road, Manchester. M13 9PT

 

Role

- Research group leader in the Respiratory Medicine group 

- Programme Director of the MRes in Tissue Engineering for Regenerative Medicine

 

Research

Tissue Repair

Tissue injury and repair in most organs involves a change in cellular composition and the remodelling of extracellular matrix components. The overall goal of our studies is to understand the fundamental cellular and molecular mechanisms involved in normal turnover of extracellular matrix molecules during tissue repair, the way these processes are altered leading to excessive healing (scarring/fibrosis) and to identify ways of regulating these processes therapeutically.

Damage to the airways through exposure to allergens, infection, tobacco smoke, and pollution can lead to serious chronic conditions such as asthma causing significant patient morbidity and mortality. While the lung displays a certain capacity for repair, often it is overwhelmed by repeated injury resulting in ‘airway wall remodelling’. Our research aims to understand the cellular and molecular mechanisms involved in airway wall remodelling by analysing clinical specimens, manipulating experimental in vivo models and developing human airway three-dimensional co-culture systems.

An extremely common problem of surgery in the abdomen is peritoneal adhesion formation where organs, which should normally be separate, become joined by fibrous bands of tissue. Peritoneal adhesions can cause major complications such as intestinal obstruction, chronic pelvic pain and infertility in women. Our previous histological and ultrastructural studies have shown that adhesions were well vascularised and surprisingly well innervated. Current studies are aimed at understanding the role of the initial wound matrix, deposited as a fibrin-rich clot between injured surfaces, and the fibrinolytic proteases involved in its breakdown. We have shown that a defect in fibrin removal results in an accumulation of collagen which leads to subsequent fibrosis and adhesion formation. Another area of interest is identifying a peritoneal ‘stem’ cell and how this may be involved in repair and adhesion formation in the abdomen.

 

 

 

Methodological Knowledge

We are using a number of experimental systems including three-dimensional cell culture systems, in vivo experimental models and human biopsy tissue analysis, as well as a range of cellular, histological, molecular and biochemical techniques to elucidate mechanisms regulating tissue repair disorders.

 

Teaching

Programme Director of the MRes in Tissue Engineering for Regenerative Medicine

 

Collaborators and affiliated staff

Dr Robin Gore; Honorary Consultant in Repiratory Medicine

Dr Dave Thornton Faculty of Life Sceinces

Miss Gaynor Campbell, PhD student

 

Publications

2011

  • S. Wilkosz, N Pullen, A de-Giorgio-Miller, G. Ireland, S. Herrick. (2011). Cellular exchange in an endometriosis adhesion model using GFP transgenic mice. Gynecologic and Obstetric Investigation, 72, 90-97. eScholarID:147630 | DOI:10.1159/000325826
  • Wright, B., Summers, A., Fenner, J., Gillott, R., Hutchinson, C., Spencer, P., Wilkie, M., Hurst, H., Herrick, S., Brenchley, P., Augustine, T. & Bardhan, K (2011). Initial observations using a novel "cine" magnetic resonance imaging technique to detect changes in abdominal motion caused by encapsulating peritoneal sclerosis. Perit Dial Int, 31(3), 287-90. eScholarID:127826 | PMID:21454394 | DOI:10.3747/pdi.2010.00078

2010

  • Herrick S, Wilson M. (2010). Targeting fibrinolysis as a therapeutic strategy to prevent abdominal adhesion formation. In Chandan Sen (Ed.), Advances in Wound Care. Volume 2. (pp. 205-209). eScholarID:147372
  • Jiang, X., Tsitsiou, E., Herrick, S. & Lindsay, M (2010). MicroRNAs and the regulation of fibrosis. FEBS J, 277(9), 2015-21. eScholarID:106063 | PMID:20412055 | DOI:10.1111/j.1742-4658.2010.07632.x
  • Lansley, S., Searles, R., Hoi, A., Thomas, C., Moneta, H., Herrick, S., Thompson, P., Newman, M., Sterrett, G., Prêle, C. & Mutsaers, S (2010). MESOTHELIAL CELL DIFFERENTION INTO OSTEOBLAST- AND ADIPOCYTE-LIKE CELLS. J Cell Mol Med, eScholarID:106062 | PMID:21070599 | DOI:10.1111/j.1582-4934.2010.01212.x

2009

  • Williams A, Larner-Svensson H, Perry M, Campbell G, Herrick SE, Adcock I, Erjefalt J, Chung K, Lindsay MMA. (2009). MicroRNA expression profiling in mild asthmatic human airways and effect of corticosteroid therapy. PLoS One, 4( 6), eScholarID:1d19825 | DOI:10.1371/journal.pone.0005889

2008

  • Langton A, Herrick SE, Headon D. (2008). An extended epidermal response heals cutaneous wounds in the absence of a hair follicle stem cell contribution. J Invest Dermatol, 128( 5), 1311-8. eScholarID:1d20947 | DOI:10.1038/sj.jid.5701178
  • Wilkosz S, Epstein J, de Giorgio-Miller A, McLean W, Ireland G, Herrick SE. (2008). Remodelling of adipose tissue during experimental omental adhesion formation. Br J Surg, 95( 3), 387-96. eScholarID:1d20946 | DOI:10.1002/bjs.6073

2007

  • Herrick SE, Mutsaers S. (2007). The potential of mesothelial cells in tissue engineering and regenerative medicine applications. Int J Artif Organs, 30( 6), eScholarID:1d20949
  • Mutsaers S, Prêle C, Lansley S, Herrick SE. (2007). The origin of regenerating mesothelium: a historical perspective. Int J Artif Organs, 30( 6), eScholarID:1d20950
  • O'Ceallaigh S, Herrick SE, Bennett W, Bluff J, Ferguson M, McGrouther D. (2007). Perivascular cells in a skin graft are rapidly repopulated by host cells. J Plast Reconstr Aesthet Surg, 60( 8), 864-75. eScholarID:1d18605 | DOI:10.1016/j.bjps.2006.03.036
  • Warde D, Herrick SE, Hunt JA. (2007). Autologous fat transplantation and adipose tissue in tissue engineering. Int J Adipose Tissue, 1, 42-48. eScholarID:61983

2006

  • Herrick SE, Mutsaers SE. (2006). Hepatocyte Growth factor. In Laurent G, Sharpiro S (Ed.), eScholarID:3c103
  • Epstein J, Wilson M, Wilkosz S, Ireland G, O'Dwyer S, Herrick SE. (2006). Human peritoneal adhesions show evidence of tissue remodeling and markers of angiogenesis. Dis Colon Rectum, 49( 12), 1885-92. eScholarID:1d15029
  • O'Ceallaigh S, Herrick SE, Bluff J, McGrouther D, Ferguson M. (2006). Quantification of total and perfused blood vessels in murine skin autografts using a fluorescent double-labeling technique. Plast Reconstr Surg, 117( 1), 140-51. eScholarID:1d12981

2005

  • de Giorgio-Miller A, Bottoms S, Laurent G, Carmeliet P, Herrick S. (2005). Fibrin-induced skin fibrosis in mice deficient in tissue plasminogen activator. American journal of pathology, 167(3), 721-732. eScholarID:1c4270
  • Degiorgio-Miller A, Treharne L, McAnulty R, Coleridge Smith P, Laurent G, Herrick SE. (2005). Procollagen type I gene expression and cell proliferation are increased in lipodermatosclerosis. Br J Dermatol, 152( 2), 242-9. eScholarID:1d15031
  • Gorvy D, Herrick S, Shah M, Ferguson M. (2005). Experimental manipulation of transforming growth factor-B iosforms significantly affects adhesion formation in a murine surgical model. American journal of pathology, 167(4), 1005-1019. eScholarID:1c4269
  • Murphy, M., Ghosh, J., Khwaja, N., Halka, A., Herrick, S., Fulford, P. & Wlaker, M (2005). Growth factor and growth factor receptor expression in healing ischaemic ulcers. BRITISH JOURNAL OF SURGERY, 92, 80-80. eScholarID:127819
  • Shuttleworth, L., Black, R., Ferguson, M. & Herrick, S (2005). Deposition of elastic fibres in a murine cutaneous wound-healing model. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 86(6), A68-A68. eScholarID:127820
  • Wilkosz S, Ireland G, Khwaja N, Walker M, Butt R, de Giorgio-Miller A, Herrick SE. (2005). A comparative study of the structure of human and murine greater omentum. Anat Embryol 209: 251-261, 209, 251-261. eScholarID:1c3739

2004

  • Herrick SE, Mutsaers SE. (2004). Mesothelial progenitor cells and their role in tissue engineering. International Journal of Biochemistry and Cell Biology, 36, 621-642. eScholarID:1c2509

2003

  • Rajnoch C, Ferguson S, Metcalfe AD, Herrick SE, Willis HS, Ferguson MWJ. (2003). Regeneration of the ear following wounding in different mouse strains is dependent on the severity of wound trauma. Developmental Dynamics, 226, 388-397. eScholarID:1c2923

2002

  • Foley-Comer A, Herrick SE, Al-Mishlab T, Prêle C, Laurent G, Mutsaers S. (2002). Evidence for incorporation of free-floating mesothelial cells as a mechanism of serosal healing. J Cell Sci, 115( Pt 7), 1383-9. eScholarID:1d31253
  • Herrick SE, Treharne L, deGiorgio-Miller A. (2002). Dermal changes in the lower leg skin of patients with venous hypertension. Int J Low Extrem Wounds, 1( 2), 80-6. eScholarID:1d31356
  • Sulaiman H, Dawson L, Laurent GJ, Bellingan GJ, Herrick SE. (2002). Role of plasminogen activators in peritoneal adhesion formation. Biochemical Society transactions, 30(2), 126-31. eScholarID:1c1716 | PMID:12023839

2001

  • Sulaiman H, Gabella G, Davis MSc C, Mutsaers S, Boulos P, Laurent G, Herrick SE. (2001). Presence and distribution of sensory nerve fibers in human peritoneal adhesions. Ann Surg, 234( 2), 256-61. eScholarID:1d31226
  • Warn, R, Harvey, P, Warn, A, Foley-Comer, A, Heldin, P, Versnel, M, Arakaki, N, Daikuhara, Y, Laurent, G, Herrick, SE, Mutsaers, S. (2001). HGF/SF induces mesothelial cell migration and proliferation by autocrine and paracrine pathways. Exp Cell Res, 267( 2), 258-66. eScholarID:1d31270

2000

  • Herrick SE, Mutsaers S, Ozua P, Sulaiman H, Omer A, Boulos P, Foster M, Laurent G. (2000). Human peritoneal adhesions are highly cellular, innervated, and vascularized. J Pathol, 192( 1), 67-72. eScholarID:1d31260
  • Jenkins R, Herrick SE, Meng Q, Kinnon C, Laurent G, McAnulty R, Hart S. (2000). An integrin-targeted non-viral vector for pulmonary gene therapy. Gene Ther, 7( 5), 393-400. eScholarID:1d31271
  • Sulaiman H, Gabella G, Davis C, Mutsaers S, Boulos P, Laurent G, Herrick SE. (2000). Growth of nerve fibres into murine peritoneal adhesions. J Pathol, 192( 3), 396-403. eScholarID:1d31259

1999

  • Herrick SE, Blanc-Brude O, Gray A, Laurent G. (1999). Fibrinogen. Int J Biochem Cell Biol, 31( 7), 741-6. eScholarID:1d21845
  • Shah M, Revis D, Herrick SE, Baillie R, Thorgeirson S, Ferguson M, Roberts A. (1999). Role of elevated plasma transforming growth factor-beta1 levels in wound healing. Am J Pathol, 154( 4), 1115-24. eScholarID:1d21846

1997

  • Ashcroft G, Herrick SE, Tarnuzzer R, Horan M, Schultz G, Ferguson M. (1997). Human ageing impairs injury-induced in vivo expression of tissue inhibitor of matrix metalloproteinases (TIMP)-1 and -2 proteins and mRNA. J Pathol, 183( 2), 169-76. eScholarID:1d31254
  • Ashcroft G, Horan M, Herrick SE, Tarnuzzer R, Schultz G, Ferguson M. (1997). Age-related differences in the temporal and spatial regulation of matrix metalloproteinases (MMPs) in normal skin and acute cutaneous wounds of healthy humans. Cell Tissue Res, 290( 3), 581-91. eScholarID:1d31227
  • Herrick, S., Ashcroft, G., Ireland, G., Horan, M., McCollum, C. & Ferguson, M (1997). Up-regulation of elastase in acute wounds of healthy aged humans and chronic venous leg ulcers are associated with matrix degradation. Lab Invest, 77(3), 281-8. eScholarID:127825 | PMID:9314951

1996

  • Ferguson M, Herrick SE, Spencer M, Shaw J, Boulton AJM, Sloan P. (1996). The histology of diabetic foot ulcers. Diabet Med, 13 Suppl 1, S30-3. eScholarID:1d31609
  • Herrick SE, Ireland G, Simon D, McCollum C, Ferguson M. (1996). Venous ulcer fibroblasts compared with normal fibroblasts show differences in collagen but not fibronectin production under both normal and hypoxic conditions. J Invest Dermatol, 106( 1), 187-93. eScholarID:1d31275

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