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School of Medicine

Dr Stephen Fowler MD

Photograph of Stephen Fowler

Lecturer and Honorary Consultant in Respiratory Medicine

Respiratory Research Group

Education and Research Centre

Wythenshawe Hospital

Southmoor Road

Manchester

M23 9LT

 

Role

Lecturer in the Respiratory Research Group, School of Translational Medicine (principally at the Wythenshawe Hospital site)Honorary Consultant in Repsiratory Medicine at Lancashire Teaching Hospitals NHS Trust (Royal Preston and Chorley District Hospitals).

 

Research

Asthma phenotyping

We are investigating the factors that are important in determining asthma severity and progression by collecting comprehensive longitudinal data in subjects with the asthma syndrome. Asthma phenotypes identified in this way will then be further defined in terms of both novel and established biomarkers, genetic-association studies, and treatment response. This approach will inform future standards for asthma diagnosis, and may lead to the development of targeted therapeutic strategies in specific subgroups.
 

 

Breath metabolomics

Characterisation of the metabolomic profile of volatile organic compounds in the exhaled breath of patients with respiratory disease may provide us with novel mechanistic insights, as well as biomarkers potentially suitable for future use in diagnosis and monitoring. We are developing breath sampling systems suitable for this purpose in patients with respiratory compromise, as well as investigating appropriate sensor technologies and data analysis protocols capable of detecting and processing such data-rich samples.
 

 

Biography

Graduated from the Universities of St Andrews and Manchester (1995), worked as a house officer and senior house officer at various hospitals in the North West, obtaining MRCP (1999) whilst on the medical rotation at North Manchester General Hospital. 

1999-2001. Clinical Research Fellow in the Department of Clinical Pharmacology, Ninewells Hospital, Dundee (Supervisor: Prof Brian Lipworth).  “Clinical Application of Bronchial Challenge in Asthma: its Relation to Markers of Severity and Dose-Response during Treatment with Inhaled Corticosteroids”, awarded MD University of Manchester 2003.  

2001 - 2005. Specialist Registrar training in respiratory and general medicine in East Anglia, and included sub-specialty training in pulmonary hypertension and cystic fibrosis at Papworth Hospital. 

Took up current post in January 2006.  Clinical interests include asthma and non-CF broncheictasis.

 

Qualifications

BSc (Med Sci) University of St Andrews 1992

MB ChB University of Manchester 1995

MRCP London 1999

MD University of Manchester 2003

 

Publications

2012

  • Basanta M, Ibrahim B, Douce D, Morris M, Woodcock A, Fowler SJ. (2012). Methodology validation, intra-subject reproducibility and stability of exhaled volatile organic compounds. eScholarID:144842
  • Ibrahim B, Marsden P, Morris J, Smith J, Nilsson M, Fowler SJ. (2012). Metabolomic Analysis of Exhaled Breath Condensate by NMR Spectroscopy Discriminates Inflammatory Phenotypes in Asthma. eScholarID:144840

2011

  • Ibrahim B, Basanta M, Cadden P, Singh D, Douce D, Woodcock A, Fowler SJ. (2011). Non-invasive phenotyping using exhaled volatile organic compounds in asthma. Thorax, doi:10.1136/thx.2010.156695. eScholarID:127622 | DOI:10.1136/thx.2010.156695
  • Maria Basanta, Baharudin Ibrahim, Rachel Dockry, David Douce, Mike Morris, Dave Singh, Ashley Woodcock, Stephen J. Fowler. (2011). Exhaled Volatile Organic Compounds for Phenotyping Chronic Obstructive Pulmonary Disease. eScholarID:127623

2010

  • Basanta, M., Jarvis, R., Xu, Y., Blackburn, G., Tal-Singer, R., Woodcock, A., Singh, D., Goodacre, R., Thomas, C. & Fowler, S (2010). Non-invasive metabolomic analysis of breath using differential mobility spectrometry in patients with chronic obstructive pulmonary disease and healthy smokers. Analyst, 135(2), 315-20. eScholarID:79581 | PMID:20098764 | DOI:10.1039/b916374c

2009

  • Fowler SJ, Langley SJ, Truman NJ, Simpson A, Woodcock AA, Custovic A. (2009). The long term effects of allergen sensitization and exposure in adult asthma: a prospective study. World Allergy Organization Journal, 2, 83-90. eScholarID:8202 | DOI:10.1097/WOX.0b013e3181a45f96

2008

  • John Firth, Paul Roberts, Stephen Fowler. (Ed.) (2008). Medical Masterclass. Royal College of Physicians of London. eScholarID:8116
  • (2008). Multiple Chapters. In John Firth, Paul Roberts, Stephen Fowler (Ed.), Medical Masterclass. (pp. -). Royal College of Physicians of London. eScholarID:8135
  • (2008). Respiratory System. In John Firth (Ed.), Medical Masterclass. (pp. -). Royal College of Physicians of London. eScholarID:8150

2007

  • Basanta M, Singh D, Fowler S, Wilson I, Dennis R, Thomas CL. (2007). Increasing analytical space in gas chromatography-differential mobility spectrometry with dispersion field amplitude programming. Journal of chromatography A, 1173, 129-138. eScholarID:8159

2006

  • Fowler SJ, French J, Screaton N, Foweraker J, Condliffe A, Haworth C, Exley A, Bilton D. (2006). Nontuberculous mycobacteria in bronchiectasis: prevalence and patient characteristics. Eur Respir J, 28( 6), 1204-10. eScholarID:1d30600

2003

  • Currie G, Fowler SJ, Lipworth B. (2003). Dose response of inhaled corticosteroids on bronchial hyperresponsiveness: a meta-analysis. Ann Allergy Asthma Immunol, 90( 2), 194-8. eScholarID:1d30221
  • Currie G, Haggart K, Lee D, Fowler SJ, Wilson A, Brannan J, Anderson S, Lipworth B. (2003). Effects of mediator antagonism on mannitol and adenosine monophosphate challenges. Clin Exp Allergy, 33( 6), 783-8. eScholarID:1d12405 | DOI:10.1046/j.1365-2222.2003.01688.x
  • Currie G, Lee D, Dempsey O, Fowler SJ, Cowan L, Lipworth B. (2003). A proof of concept study to evaluate putative benefits of montelukast in moderate persistent asthmatics. Br J Clin Pharmacol, 55( 6), 609-15. eScholarID:1d30137
  • Fowler SJ, Lipworth B. (2003). Relationship of skin-prick reactivity to aeroallergens and hyperresponsiveness to challenges with methacholine and adenosine monophosphate. Allergy, 58( 1), 46-52. eScholarID:1d12406 | DOI:10.1034/j.1398-9995.2003.23779.x
  • Orr L, Fowler SJ, Lipworth B. (2003). Relationship between changes in quality of life and measures of lung function and bronchial hyper-responsiveness during high-dose inhaled corticosteroid treatment in uncontrolled asthma. Am J Respir Med, 2( 5), 433-8. eScholarID:1d30018

2002

  • Currie G, Fowler SJ, Wilson A, Sims E, Orr L, Lipworth B. (2002). Airway and systemic effects of hydrofluoroalkane fluticasone and beclomethasone in patients with asthma. Thorax, 57( 10), 865-8. eScholarID:1d30228
  • Dempsey O, Fowler SJ, Wilson A, Kennedy G, Lipworth B. (2002). Effects of adding either a leukotriene receptor antagonist or low-dose theophylline to a low or medium dose of inhaled corticosteroid in patients with persistent asthma. Chest, 122( 1), 151-9. eScholarID:1d30577
  • Fowler SJ, Currie G, Lipworth B. (2002). Step-down therapy with low-dose fluticasone-salmeterol combination or medium-dose hydrofluoroalkane 134a-beclomethasone alone. J Allergy Clin Immunol, 109( 6), 929-35. eScholarID:1d12408 | DOI:10.1067/mai.2002.123869
  • Fowler SJ, Hall I, Wilson A, Wheatley A, Lipworth B. (2002). 5-Lipoxygenase polymorphism and in-vivo response to leukotriene receptor antagonists. Eur J Clin Pharmacol, 58( 3), 187-90. eScholarID:1d30794
  • Fowler SJ, Orr L, Sims E, Wilson A, Currie G, McFarlane L, Lipworth B. (2002). Therapeutic ratio of hydrofluoroalkane and chlorofluorocarbon formulations of fluticasone propionate. Chest, 122( 2), 618-23. eScholarID:1d12407

2001

  • Fowler SJ, Lipworth B. (2001). Pharmacokinetics and systemic beta2-adrenoceptor-mediated responses to inhaled salbutamol. Br J Clin Pharmacol, 51( 4), 359-62. eScholarID:1d29915
  • Fowler SJ, Lipworth B. (2001). Salmeterol and inhaled corticosteroids in patients with persistent asthma. JAMA, 286( 24), 3076-7; author reply 3077-8. eScholarID:1d30573
  • Fowler SJ, Orr L, Wilson A, Sims E, Lipworth B. (2001). Dose-response for adrenal suppression with hydrofluoroalkane formulations of fluticasone propionate and beclomethasone dipropionate. Br J Clin Pharmacol, 52( 1), 93-5. eScholarID:1d31209
  • Fowler SJ, Wilson A, Griffiths E, Lipworth B. (2001). Comparative in vivo lung delivery of hydrofluoroalkane-salbutamol formulation via metered-dose inhaler alone, with plastic spacer, or with cardboard tube. Chest, 119( 4), 1018-20. eScholarID:1d29916
  • Wilson A, Fowler SJ, Martin S, White P, Gardiner Q, Lipworth B. (2001). Evaluation of the importance of head and probe stabilisation in acoustic rhinometry. Rhinology, 39( 2), 93-7. eScholarID:1d30795

2000

  • Fowler SJ, Dempsey O, Sims E, Lipworth B. (2000). Screening for bronchial hyperresponsiveness using methacholine and adenosine monophosphate. Relationship to asthma severity and beta(2)-receptor genotype. Am J Respir Crit Care Med, 162( 4 Pt 1), 1318-22. eScholarID:1d30085

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